Forbes Advisor said it came up with the rankings, "by pulling recent data on key lifestyle factors such as the area's median home price, personal income per capita, and the unemployment and crime rate." While Jacksonville holds the honor of being Florida's largest city by population, its combined metro area population is smaller than Miami and Tampa. You can enjoy big city conveniences and live on the Atlantic Ocean"yet the living costs are relatively affordable. "Banking, healthcare and transportation are the seven-county metro area's biggest employment opportunities. The city is also home to one of the nation's three Mayo Clinics and offers access to many of Florida's best banks."