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JPW have any comments on this?

www.nature.com

By contrast, a counterintuitive result of our analysis is that the highest risk of resistant strain establishment occurs when a large fraction of the population has already been vaccinated but the transmission is not controlled.

Exactly where we are at right now.

The question of which breakthroughs matter ultimately depends on another: What's the goal of vaccination? Gounder thinks that, for now, the focus should stay on using immunizations to control COVID-19, especially while so much of the world remains unvaccinated; understanding whether we're accomplishing that goal, then, hinges on symptomatic breakthroughs.

The goal is not good with the current leaky vaccines. It is driving artifical selection for more variants and fit phenotypes. That's the big problem... and we are/shall see it grow exponentially worse as more people are vaccinated.

www.geertvandenbossche.org

non-vaccinated people are not to be considered factories of variants as there is no evidence whatsoever that they transmit more virus or shed for a longer time than asymptomatically infected vaccinees. As explained in the above-mentioned article, non-vaccinated people are not responsible for selecting immune escape variants and enabling adaptation of increasingly anti-S Ab-resistant variants. Vaccinees, however, are to be seen as the breeding ground and pilot plants' for these variants.

Let's now comment on a few of these blunt statements:

"Unvaccinated people do more than merely risk their own health. They're also a risk to everyone if they become infected with coronavirus, infectious disease specialists say"

Comment: Not true. Unvaccinated people have the more reliable protection as they can deal with all Sars-CoV-2 variants. Their protection is merely threatened by the enhanced circulation of more infectious variants, the adaptation and spread of which is promoted by those who exert strong (but suboptimal!) immune selection pressure, i.e., vaccinees. To the extent that non-vaccinated people further adhere to infection prevention measures and -not at least - avoid close contact with vaccinees, the likelihood for them to become seriously ill remains reasonably low (but clearly higher as during the first 10 months of the pandemic where no variants were circulating). This particularly applies to children and youngsters in good health. As viral transmission by asymptomatically infected, non-vaccinated individuals is low and short-lived, they do not constitute a factory' of variants that poses a substantial risk to others.

"That's because the only source of new coronavirus variants is the body of an infected person."

Comment: Vaccinees get infected all the time. They cannot contain the variants as shown in a multitude of publications and breakthrough reports. They are not only a source of asymptomatic transmission but even a breeding ground for steadily evolving immune escape variants.

"Unvaccinated people are potential variant factories," Dr. William Schaffner, a professor in the Division of Infectious Diseases at Vanderbilt University Medical Center, told CNN Friday.

Comment: This doesn't make any scientific sense. See above. They should show us the data and perform a comparative analysis on vaccinees compared to non-vaccinated individuals. They should show us which group is evolving more problematic variants, the vaccinees or the non-vaccinated.

"The more unvaccinated people there are, the more opportunities for the virus to multiply," Schaffner said. "When it does, it mutates, and it could throw off a variant mutation that is even more serious down the road."

Comment: This is the ludicrous mantra of the WHO (see my previously mentioned article). What makes immune escape variants problematic is when they get selected and can subsequently adapt to the population. S-directed immune escape variants are preferably selected in vaccinees and the higher the vaccination coverage rate, the more rapidly and easily they will adapt to the population and become dominant.


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