Trump has granted clemency to several figures in major health care fraud cases. In 2020, he commuted the 20-year federal prison sentence of Philip Esformes, a Florida nursing home magnate convicted in a scheme that prosecutors said involved about $1.3 billion in fraudulent Medicare and Medicaid claims. The White House cited allegations of prosecutorial misconduct, echoing claims from Esformes' defense that prosecutors improperly invaded attorney-client privilege by reviewing documents seized in an FBI raid. Although appeals courts did not overturn the conviction based on this argument, Esformes had support from two former U.S. attorneys general.

That same year, Trump commuted the sentence of Judith Negron, convicted in a $200 million Medicare fraud case. Trump's clemency grant said the "ends of justice" did not require her to serve another two decades in prison.