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... Research published in 2022 revealed the bacterium that causes typhoid fever is evolving extensive drug resistance, and is rapidly replacing strains that aren't resistant.

Currently, antibiotics are the only effective treatment for typhoid, caused by the bacterium Salmonella enterica serovar Typhi (S. Typhi). Yet over the past three decades, the bacterium's resistance to oral antibiotics has been growing and spreading.

In their study, scientists from multiple countries sequenced the genomes of 3,489 S. Typhi strains contracted from 2014 to 2019 in Nepal, Bangladesh, Pakistan, and India, and found a rise in extensively drug-resistant (XDR) Typhi. ...