Saturday, August 24, 2024

Drug Reverses Cognitive Decline in Alzheimer's

Neuroscientists at Stanford have linked Alzheimer's disease to the disruption of brain metabolism via the kynurenine pathway, which is affected by amyloid plaque and tau proteins.

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Their research has demonstrated that drugs blocking this pathway can restore cognitive function in Alzheimer's mice by improving brain metabolism.

This discovery not only bridges the gap between neuroscience and oncology but also provides a fast track to repurposing existing drugs for Alzheimer's treatment.

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"We were surprised that these metabolic improvements were so effective at not just preserving healthy synapses, but in actually rescuing behavior. The mice performed better in cognitive and memory tests when we gave them drugs that block the kynurenine pathway," said senior author, Katrin Andreasson, a neurologist at the Stanford School of Medicine and member of the Wu Tsai Neurosciences Institute.

The study, which included collaborations with researchers at the Salk Institute for Biological Studies, Penn State University, and others, was published on August 22, 2024, in the journal Science."

Lucky mice! I just hope this treatment is available in time for Robson and Jeffy to take advantage of it!

#1 | Posted by Corky at 2024-08-23 12:18 PM

I might need this stuff soon, I'm pushing 70, and I've got that long-term/short-term memory thing going on. I can tell you things, in detail, what I did 40 or 50 years ago, but I can't remember what I had for breakfast.

#2 | Posted by shane at 2024-08-24 11:22 AM

They need to call it a vaccine so trump won't take it.

#3 | Posted by Yodagirl at 2024-08-24 11:40 AM

It would be much more productive spending 200 Billion actually curing costly disease than sending it to Ukraine and to other countries just to wage war and then convinced to rebuild the countries. Biden and the Democrat neocons want us to wage war and spend our remaining treasury on funding perpetual wars fought by their cronies.

#4 | Posted by Robson at 2024-08-24 04:28 PM

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