Typhoid fever might be rare in developed countries, but this ancient threat, thought to have been around for millennia, is still very much a danger in our modern world.
Typhoid fever might be rare in developed countries, but this ancient threat, thought to have been around for millennia, is still very much a danger in our modern world. According to research published in 2022, the bacterium that causes typhoid fever is evolving extensive drug resistance.
-- Scott Horton (@robertscotthorton.bsky.social) April 21, 2025 at 10:47 PM
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... Currently, antibiotics are the only way to effectively treat typhoid, which is caused by the bacterium Salmonella enterica serovar Typhi (S Typhi). Yet over the past three decades, the bacterium's resistance to oral antibiotics has been growing and spreading. ...
XDR Typhi is not only impervious to frontline antibiotics, like ampicillin, chloramphenicol, and trimethoprim/sulfamethoxazole, but it is also growing resistant to newer antibiotics, like fluoroquinolones and third-generation cephalosporins.
Even worse, these strains are spreading globally at a rapid rate. ...
The study was published in The Lancet Microbe. [Volume 3, Issue 8e567-e577, August 2022. www.thelancet.com(22)00093-3/fulltext ] ...
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