Tuesday, October 08, 2024

Her Face Was Burned Unrecognizable. a Placenta Restored It.

In the aftermath of a propane explosion in 2021, Marcella Townsend spent more than six weeks in an induced coma in a burn trauma unit. She had second- and third-degree burns over most of her body, and her face had become unrecognizable. Searching for a way to help her, surgeons turned to a rarely utilized tool: human placenta. They carefully applied a thin layer of the donated organ to her face. She still has scars from grafts elsewhere on her body, but the 47-year-old's face, she said, "looks exactly like it did before."

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During pregnancy, the placenta forms in the uterus, where it provides the fetus with nutrients and antibodies, and protects it from viruses and toxins. Then, it follows the baby from the body, still filled with a wealth of stem cells, collagens and cytokines that doctors and researchers have realized make it uniquely useful after birth, too.

Research has found placenta-derived grafts can reduce pain and inflammation, heal burns, prevent the formation of scar tissue and adhesions around surgical sites and even restore vision. They're also gaining popularity as a treatment for the widespread issue of chronic wounds.

And yet, of the roughly 3.5 million placentas delivered in the United States each year, most still wind up in biohazard disposal bags or hospital incinerators. That flummoxes Ms. Townsend, who returned to her job as a surgical assistant with a new perspective. "I'm constantly in these hospitals that don't donate or utilize the placental tissue," she said. "I hear the obstetrician say, I don't need to send that to pathology or anything; just trash it.' I cringe every time."

Because the placenta protects the fetus from the maternal immune system, its tissue is considered immunologically privileged: Even though it's technically foreign tissue, placental grafts have been found not to prompt an immune response in transplant recipients. That means, unlike skin grafts from animals or cadavers, placental grafts are basically not rejectable. The placenta's tissue also contains proteins and sugars that spur patients' cells to multiply quickly, and the grafts have been shown to encourage rapid skin and tissue regrowth. In one case, doctors essentially regrew the tip of someone's nose.

"We call it a healing factor, but a better way to put it is it's a regenerative factor," said Dr. Scheffer Chuei-Goong Tseng, an ophthalmologist in Miami who's spent decades studying the use of placental grafts to treat eye injuries and diseases and whose company manufactures and sells them. "Healing is broad; you can heal but still scar. We are talking about healing almost without scarring."

Fascinating. Here's a story that has little if nothing to do with partisan politics, though I'm sure the topic is a 'political' one in the medical industry. But from this layman's perspective, placenta usage seems to be almost a miraculous way to restore or regenerate human tissue that's been effectively ravaged by fire or trauma. It appears that the upside of placenta use is a no-brainer and there are likely many more uses of the tissue which haven't even been tried yet.

#1 | Posted by tonyroma at 2024-10-08 08:26 AM

Moral of the story, stop eating your placentas.

#2 | Posted by LegallyYourDead at 2024-10-08 02:35 PM

I wonder if that tissue can be produced in a lab.

(Queue partisan politics)

#3 | Posted by GalaxiePete at 2024-10-08 03:27 PM

Science for the win!

#4 | Posted by AMERICANUNITY at 2024-10-08 06:30 PM

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