A genetically drifted influenza A(H3N2) subclade K has spread to more than 34 countries since August 2025, causing hospitalizations to surge and setting records in the UK with 2,660 daily admissions. The US has recorded at least 4.6 million illnesses, 49,000 hospitalizations, and 1,900 deaths this season, with young children and older adults hit hardest.
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