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The official did not offer additional details about the incident, which has not been previously reported. The Pentagon and US President Donald Trump are yet to publicly confirm the attack.
Prior to this latest strike, the US had carried out five attacks on alleged drug smuggling vessels in the Caribbean since early September, killing at least 27 people.
The strikes have drawn the condemnation of legal experts, rights groups and Democratic lawmakers, who criticise their extrajudicial nature and question whether they adhere to US and international law.