With the H5N1 bird flu virus spreading quickly across animals in the US, experts are on high alert for signs of human-to-human transmission. Such a jump could become far easier with just a single mutation, according to new research.
A single mutation could allow the bird flu virus to infect the cells lining our noses and throats, making it more likely to go airborne. www.newscientist.com/article/2459 ...
-- New Scientist (@newscientist.bsky.social) December 11, 2024 at 4:58 AM
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@#2 ... "New Pandemic"?
And look see who we've got to protect us after 01/20/25. ...
Yeah, that was (is) my concern also.
And a reason why I was initially reluctant to post this thread.
So far, the possible outcome in the article is just that, as the article states -- a possible outcome.
At this point, I am quite happy it is being monitored by government medical professionals.
fwiw, here's the original (and, if i may add, apparently not yet peer-reviewed) research article...
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
www.science.org
...
Editor's summary
In 2021, a highly pathogenic influenza H5N1 clade 2.3.4.4b virus was detected in North America that is capable of infecting a diversity of avian species, marine mammals, and humans. In 2024, clade 2.3.4.4b virus spread widely in dairy cattle in the US, causing a few mild human cases, but retaining specificity for avian receptors.
Historically, this virus has caused up to 30% fatality in humans, so Lin et al. performed a genetic and structural analysis of the mutations necessary to fully switch host receptor recognition.
A single glutamine to leucine mutation at residue 226 of the virus hemagglutinin was sufficient to enact the change from avian to human specificity.
In nature, the occurrence of this single mutation could be an indicator of human pandemic risk. "Caroline Ash
...
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