Sunday, June 22, 2025

One shot to stop HIV: MIT's bold vaccine breakthrough

By delivering an HIV vaccine candidate along with two adjuvants, researchers showed they could generate many more HIV-targeting B cells in mice.

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... Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies.

This one-shot strategy could revolutionize how we fight not just HIV, but many infectious diseases.

It mimics the natural infection process and opens the door to broadly neutralizing antibody responses, a holy grail in vaccine design. And best of all, it's built on components already known to medicine. ...



#1 | Posted by LampLighter at 2025-06-22 09:50 PM

Republicans: "We better pull funding asap!"

#2 | Posted by Sycophant at 2025-06-23 11:35 AM

Eh.

Broadly neutralizing antibodies has continued to be an oversold premise in regards to making vaccines that are "universal."

There was a guy at Mount Sinai who pushed universal influenza vaccines for decades with cross reactive antibodies being a major pillar of the approach.

Well, as it turns out, improved methodologies to measure and characterize B cell responses have shown that we make cross reactive antibodies during natural infection, often to targets that were thought holy grails of a "universal" response (ie the stalk region of influenza HA protein).

But we clearly don't develop "universal" responses that negate the need for seasonal influenza vaccines.

I suspect this vaccine will end up the same way.

#3 | Posted by jpw at 2025-06-24 01:32 PM

Thanks for the analysis. JPW

#4 | Posted by Miranda7 at 2025-06-25 02:51 AM

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