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One shot to stop HIV: MIT's bold vaccine breakthrough
By delivering an HIV vaccine candidate along with two adjuvants, researchers showed they could generate many more HIV-targeting B cells in mice.
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LampLighter
Joined 2013/04/13Visited 2025/06/25
Status: user
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... Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies. This one-shot strategy could revolutionize how we fight not just HIV, but many infectious diseases. It mimics the natural infection process and opens the door to broadly neutralizing antibody responses, a holy grail in vaccine design. And best of all, it's built on components already known to medicine. ...
This one-shot strategy could revolutionize how we fight not just HIV, but many infectious diseases.
It mimics the natural infection process and opens the door to broadly neutralizing antibody responses, a holy grail in vaccine design. And best of all, it's built on components already known to medicine. ...
#1 | Posted by LampLighter at 2025-06-22 09:50 PM | Reply
Republicans: "We better pull funding asap!"
#2 | Posted by Sycophant at 2025-06-23 11:35 AM | Reply
Eh.
Broadly neutralizing antibodies has continued to be an oversold premise in regards to making vaccines that are "universal."
There was a guy at Mount Sinai who pushed universal influenza vaccines for decades with cross reactive antibodies being a major pillar of the approach.
Well, as it turns out, improved methodologies to measure and characterize B cell responses have shown that we make cross reactive antibodies during natural infection, often to targets that were thought holy grails of a "universal" response (ie the stalk region of influenza HA protein).
But we clearly don't develop "universal" responses that negate the need for seasonal influenza vaccines.
I suspect this vaccine will end up the same way.
#3 | Posted by jpw at 2025-06-24 01:32 PM | Reply
Thanks for the analysis. JPW
#4 | Posted by Miranda7 at 2025-06-25 02:51 AM | Reply
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