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Cause of Alzheimer's Might Be Coming from Inside Your Mouth
In recent years, a growing number of scientific studies have backed an alarming hypothesis: Alzheimer's disease isn't just a disease, it's an infection.
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LampLighter
Joined 2013/04/13Visited 2025/03/13
Status: user
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... While the exact mechanisms of this infection are something researchers are still trying to isolate, numerous studies suggest the deadly spread of Alzheimer's goes way beyond what we used to think. One such study, published in 2019, suggested what could be one of the most definitive leads yet for a bacterial culprit behind Alzheimer's, and it comes from a somewhat unexpected quarter: gum disease. In a paper led by senior author Jan Potempa, a microbiologist from the University of Louisville, researchers reported the discovery of Porphyromonas gingivalis -- the pathogen behind chronic periodontitis (aka gum disease) -- in the brains of deceased Alzheimer's patients. It wasn't the first time the two factors have been linked, but the researchers went further. In separate experiments with mice, oral infection with the pathogen led to brain colonization by the bacteria, together with increased production of amyloid beta (A), the sticky proteins commonly associated with Alzheimer's. ...
One such study, published in 2019, suggested what could be one of the most definitive leads yet for a bacterial culprit behind Alzheimer's, and it comes from a somewhat unexpected quarter: gum disease.
In a paper led by senior author Jan Potempa, a microbiologist from the University of Louisville, researchers reported the discovery of Porphyromonas gingivalis -- the pathogen behind chronic periodontitis (aka gum disease) -- in the brains of deceased Alzheimer's patients.
It wasn't the first time the two factors have been linked, but the researchers went further.
In separate experiments with mice, oral infection with the pathogen led to brain colonization by the bacteria, together with increased production of amyloid beta (A), the sticky proteins commonly associated with Alzheimer's. ...
#1 | Posted by LampLighter at 2025-02-20 11:49 PM | Reply
Also, for years in Europe, Alzheimer's is often known as Diabetes type 3.
The brain is a place we will never understand.
My wife is a few years into early-onset Alzheimer's. Began in her late 50s. She's now 71. I'm her caregiver. We went through it with her mother too. It's an amazing process to watch. And even the top docs know what happens, but never really why.
#2 | Posted by Dbt2 at 2025-02-22 07:33 AM | Reply | Newsworthy 1
"It's an amazing process to watch."
There is a road, no simple highway Between the dawn and the dark of night And if you go, no one may follow That path is for your steps alone
Ripple in still water When there is no pebble tossed Nor wind to blow
You who choose to lead must follow But if you fall you fall alone If you should stand then who's to guide you? If I knew the way I would take you home
#3 | Posted by Doc_Sarvis at 2025-02-22 07:42 AM | Reply | Newsworthy 1
@#1 ... In a paper led by senior author Jan Potempa, a microbiologist from the University of Louisville, researchers reported the discovery of Porphyromonas gingivalis -- the pathogen behind chronic periodontitis (aka gum disease) -- in the brains of deceased Alzheimer's patients. ...
Goods news.
Let's hope that research can continue ...
#4 | Posted by LampLighter at 2025-02-22 10:41 PM | Reply | Newsworthy 1
" Let's hope that research can continue ..."
In related news, all NIH funding has been frozen or rescinded!
In a macro sense, does that put us closer to a cure, or further away?
/snark
#5 | Posted by Danforth at 2025-02-22 10:44 PM | Reply | Newsworthy 1
dare we say.... BIG SUGAR?
#6 | Posted by RightisTrite at 2025-02-23 10:22 AM | Reply
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