vaccines were starting to bleed into detrimental territory with effects like induction of IgG4 and even primary doses were in a breadth of adverse events that was problematic>

More evidence-free bull-sheet from our resident moron.

Please tell the class how the protein produced by mRNA from a vaccine, the same spike protein with the same transmembrane domain as COVID. In fact, the big difference between the two is that the vaccine induced spike protein does virtually nothing beyond producing a specific immune response, because it has no escape accomplices (the other components of the viral structure) to latch onto, because the cell isn't making them.

sound sciency.

You say the spike protein from the mRNA vaccine is responsible for a dubious chronic inflammatory condition, somehow different from the spike protein on COVID. Yet you can't produce any evidence for your wild assertions other than 'look it up!'.

"Do your research!" the rallying cry of the uninformed.

extensively documented.

Yeah, where? let me guess, anecdotal evidence that you see on Facebook type of documentation? Maybe VAERS? Or actual peer-reviewed studies in respected medical journals?

You blab on about 'proof' without ever producing any. Where's your link? If it's that easy to find, why can't you produce it?

You're just like every other science-illiterate Conservadunce. You regurgitate half-baked, evidence-free accusations without even understanding how dumb it is. You don't even know the basics about mRNA. It's painfully obvious.

TrumpT are the masters of Projection. You're the uninformed fool trying to appear intelligent. Emphasis on the word 'trying'.

For the record, three of the protective antibodies to COVID are anti-SARS-CoV-2 spike IgG (nCoV S-IgG), anti-SARS-CoV-2 spike receptor-binding domain IgG (nCoV RBD-IgG), and anti-SARS-CoV-2 neutralizing antibodies (nCoV NAbs).

Two of these are IgG. IgG is the most common major immune system subclass in the body. I'm guessing these morons misinterpreted a positive immune response for something more nefarious.

Or they're relying on sources like VAERS which is a common anti-vaxxer mining ground. It's not a data collection center and they explicitly state as such. But that never stopped the anti-vaxxers.

Or they made the error of attributing causation of a disease from an abnormal lab value. Even if certain lab markers (like IgG4) have been correlated with a disease, it is not like some light-switch that guarantees a diagnosis.

If you knew anything about medicine, you'd know that.

My guess is JPW never dug any deeper than "Yup! Sounds just like what my gut told me!".

Here's the reason RFKjr and JPW spew accusations but never give the goods on how they arrived at them;

Because when they try to do it, they get torn an academic a----e.

Just like the hilariously inept MAHA report. An epic flop of science-illiteracy and made-up AI crap no MAGAMORON fact-checked. It was deservedly ripped to shreds within days of arrival.

Yav - the first link throws and error that says 'for health professionals only'. Not sure how you followed that.

Now for the second and third link. Let me ask you. Did you actually read those papers? Or did you pull them up in some PubMed search and post them without any investigation?

If so, what from the papers did you find most telling? Thoughts, please!

Just from 10 minutes of reading, they do not support your 'well-correlated' claim. In fact the study in the third link clearly says this is a proposed hypothesis.

Jesus fkng christ people. Research is more than a Google search and posting the results.

Even if they did show correlation, correlation does not mean causation.

4th link - a synopsis (not the actual paper) that has nothing to do with correlation or causation with some generalized chronic inflammatory condition. An elevated lab marker may mean a lot of things or nothing at all. They didn't even mention chronic inflammation. The 4th link has to do with COVID vaccine efficacy and IgG4.

JFC You didn't actually read any of these, did you Yav?

Multiple studies show IgG4 increases following repeat boosting with mRNA COVID vaccines. That's indisputable.

You still don't get it do you?

Whether or not it raises IgG4 doesn't prove causation of an autoimmune disease. There are many markers of inflammation (such as ESR) that have a high sensitivity and low specificity. You can have an elevated Rheumatoid factor and not have rheumatoid arthritis. The IgG4 is elevated for other reasons.

What you dum-dums keep forgetting is the COVID virus has the same spike protein that produces the same immune response. That is why the vaccine is so effective. Yes there may be chronic disease, but it's been overwhelmingly been linked to the actual infection. Have you ever heard of the long-term effects of actually having COVID?

JFC.

The third article posted by Yav was that the elevated levels of IgG4 were indicative of vaccine efficacy. They did not say anything about autoimmune disease . It's right in the ------ synopsis, you dim-wits. You can gaslight each other all you want.

You think it's intellectual sophistry when you're idiots engaging in it.

You know nothing of the basics of immunology and your links do not show what you say they do. Otherwise you'd actually quote from the articles.

The cause of IgG4-RD remains unknown and many people have it outside of being vaccinated.

The intellectual contortions are all on your end. But what else would you expect from anti-vaxxer science illiterates?

These are the same people who confidently state vaccines cause Autism. Keep that in mind when you're ascertaining the level of Willful Ignorance.

Its pro-inflammatory characteristics were a positive for initial vaccinations because it gave a more "natural"-like response.

Inflammation is part and parcel of any immune response. From local to systemic infections that's the way it works.

What a discovery you've made!

But you are making a huge leap from that to chronic disease. You've provided zero proof and the links Yav posted were speculative at best or did not have anything to do with IgG4-RD disease at all.

If all you're saying is it raises IgG4 then fine. If you're not alleging it's related to anything beyond temporary increase in inflammatory markers then why are you bringing it up in the first place?

The Anti-Vaxxer two-step. Raise dubious, vague concerns then backtrack when confronted with specifics.