In college, we found Psilocybin 'shrooms in east TX pastures under dried cow patties; much calmer than acid, and my best comp is living in a Roger Rabbit movie.

And the cows didn't mind, but sometimes the farmers did!

Of course, I was just experimenting for my psych major... that's my story, and I'm sticking to it.

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Here's the original study for the article... it's not a, 'systematic investigation', but it tends to point towards one being warranted.

from the Nat Inst of Health study linked above:

"Conclusions and perspectives

Recent strides in utilizing psilocybin for the treatment of neuropsychiatric disorders exhibit considerable promise.

Psilocybin holds potential for conferring distinctive advantages in terms of neuroprotection and cognitive enhancement for individuals with Alzheimer's disease (AD) through mechanisms such as neuroplasticity, inflammation regulation, and enhanced neuropsychology.

Furthermore, the antidepressant and anti-anxiety effects of psilocybin may signify substantial advancements in addressing the mental well-being of patients with neuropsychiatric conditions associated with AD.

Nonetheless, it is imperative to recognize that a substantial journey lies ahead before psilocybin can be judiciously and efficaciously employed in AD patient care."

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One of the things they describe doing is to try to separate the hallucinatory effects from the effective therapeutic effects than tend to act like antidepressants which adjust levels of neurotransmitters like serotine; they act as the same 5-HT2A agonists or antagonists.