In college, we found Psilocybin 'shrooms in east TX pastures under dried cow patties; much calmer than acid, and my best comp is living in a Roger Rabbit movie.

And the cows didn't mind, but sometimes the farmers did!

Of course, I was just experimenting for my psych major... that's my story, and I'm sticking to it.

;;
Here's the original study for the article... it's not a, 'systematic investigation', but it tends to point towards one being warranted.

from the Nat Inst of Health study linked above:

"Conclusions and perspectives

Recent strides in utilizing psilocybin for the treatment of neuropsychiatric disorders exhibit considerable promise.

Psilocybin holds potential for conferring distinctive advantages in terms of neuroprotection and cognitive enhancement for individuals with Alzheimer's disease (AD) through mechanisms such as neuroplasticity, inflammation regulation, and enhanced neuropsychology.

Furthermore, the antidepressant and anti-anxiety effects of psilocybin may signify substantial advancements in addressing the mental well-being of patients with neuropsychiatric conditions associated with AD.

Nonetheless, it is imperative to recognize that a substantial journey lies ahead before psilocybin can be judiciously and efficaciously employed in AD patient care."

;;

One of the things they describe doing is to try to separate the hallucinatory effects from the effective therapeutic effects than tend to act like antidepressants which adjust levels of neurotransmitters like serotine; they act as the same 5-HT2A agonists or antagonists.

#5

I would consider that in a controlled study or treatment center. Some of the success in small studies is impressive, but the process needs monitoring.

"Chronic neuroinflammation plays a significant role in Alzheimer's disease (AD) pathogenesis associated with a decline in cognitive and mood function. Currently, there are no effective therapies to alleviate the progression of brain dysfunction in AD.

Psilocybin, an FDA-approved drug for treating major depressive disorder, can restrain neuroinflammation and improve hippocampal neurogenesis. Therefore, the current study investigated the efficacy of psilocybin treatment in slowing down cognitive decline in 5x familial AD (5xFAD) mice."

Conclusions
Psilocybin treatment can maintain better brain function in an AD model without affecting amyloid-beta plaques. Improved brain function is likely due to psilocybin-induced reductions in neuroinflammatory signaling, enhanced hippocampal neurogenesis, and preservation of synapses."

#7

;p ha... I'm afraid I'm a bit out of practice, thought a couple of years ago I did try a psilocybin micro dose, which was, um, interesting, but nothing like back in the day.

- how much acid have you dropped?

I took one of my Finals psyche tests, a 400 multiple choice question test with paragraph long questions and answers, after I thought I had peaked on some Orange Barrels (or something) from the night before.

Walked in sat down, put my pencil to the paper, it flashed a bright light, and I said, "Rut-ro"! Looked at the first 4 questions, couldn't make heads or tails of the questions or the answers.

Then, next thing I knew I was coming down again for real, and handing in the test.

I just knew I had screwed up badly. A couple of days later the results were posted; I missed the first 4 questions and got all the rest right!