'History's first U.S.-born pope didn't mention the United States or President Donald Trump in his prayer, which was planned before the talks were announced.
But Leo's tone and message appeared directed at Trump and U.S. officials, who have boasted of U.S. military superiority and justified the war in religious terms.
"Enough of the idolatry of self and money!" Leo said. "Enough of the display of power! Enough of war!"
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"Praying for peace, Leo said, was a way to "break the demonic cycle of evil" to build instead the Kingdom of God where there are no swords, drones or "unjust profit."
"It is here that we find a bulwark against that delusion of omnipotence that surrounds us and is becoming increasingly unpredictable and aggressive," he said. "Even the holy Name of God, the God of life, is being dragged into discourses of death."
Leaders have used religion to justify their actions in the war. U.S. officials and especially Defense Secretary Pete Hegseth have invoked their Christian faith to cast the U.S. as a Christian nation trying to vanquish its foes.
Leo has said God doesn't bless any war, and certainly not those who drop bombs."