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The top causes of death in the US in 2025 followed longstanding patterns: Heart disease led with nearly 695,000 deaths, followed by cancer with nearly 623,000 deaths. Unintentional injuries, which includes drug overdoses, were the third leading cause of death. Overdose deaths are still high " about 70,000 people died from an overdose in 2025, preliminary CDC data shows " but experts say that sharp declines probably played a large role in bringing the age-adjusted death rate down in the US.